Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol>
菊谷 仁
B6.129P2-Cd40<tm1Kik>/Rbrc
herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Tnfrsf5 genomic DNA
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Immunity, 1, 167-178 (1994).
CD40 knockout mice. Exon 3 of the CD40 was replaced with a neo cassette. CD40/Tnfrsf5 (tumor necrosis factor receptor superfamily, member 5) is essential for T cell-dependent immunoglobulin class switching and germinal center formation. Homozygous mutant mice for CD40 targeted mutation exhibit impaired immunoglobulin class switching, and the germinal center formation was defective. Homozygous mice are viable and fertile.
RBRC00752
大阪大学細胞工学センター・菊谷 仁先生(1994)。
Immunology and Inflammation Research
CD40 Knockout mice
Hitoshi KIKUTANI
Developed by Hitoshi Kikutani, Institute for Molecular and Cellular Biology, Osaka University in 1994.
大阪大学
Osaka Univ.
CD40 Knockout mice, B6.129P2-CD40<tm1Kik>/Rbrc, B6.129P2-Tnfrsf5<tm1Kik>/Rbrc
CD40 Knockout mice, B6.129P2-CD40<tm1Kik>/Rbrc, B6.129P2-Tnfrsf5<tm1Kik>/Rbrc
条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Immunity, 1, 167-178 (1994).
true
C (3-6 months)
CD40ノックアウトマウス。エクソン3をneoカセットで置換。
<a href='https://brc.riken.jp/mus/pcr00752'>Genotyping protocol -PCR-</a>
E14.1 [129P2/OlaHsd]
C(3〜6か月)